Research and practice demonstrates that there is sufficient data available on the risk and protective factors relevant to effective prevention strategies for reducing gender-based violence among youth. Implementation by advocacy organizations is widely varied and inadequate. Multiple barriers exist for advocacy organizations attempting to conduct prevention activities. Minimal research or guidance is provided on the effective organizational structure or the components to support a fully functioning prevention program. This paper synthesizes existing research on comprehensive prevention strategies with youth and conducts original research on advocacy organizations in two states to draw conclusions and recommendations on structural development within agencies for improved youth prevention programs.